Assessment of prescribing pattern of anti hypertensive therapy in diabetic patients visiting in government hospital of Dolakha

Abstract

Introduction: Hypertension and Diabetes Mellitus are two major chronic disorders that frequently coexist progressively with age irrespective of gender. WHO has projected that about 300 million people will suffer from diabetes and 1.5 billion from Hypertension by 2025. Both Hypertension and type II Diabetes are strongly interconnected and predispose an individual to atherosclerotic cardiovascular disease. As the patients require long life treatment, it has increased the burden of patients particularly in developing country like Nepal. In hospitals, there is genuine need for drug utilization study to determine appropriate, more safe and effective patterns of drug therapy among diabetic hypertensive patients.
Methods: A single centered retrospective specify how the study is retrospective cross sectional study was conducted in Jiri Hospital, Dolakha from Feb 2022 to July 2022. A total of 148 prescriptions of the patient with hypertension and coexisting diabetes were analyzed.
Results: The age group of the patients varied from 30-99 years with dominant age interval being32.4% of 50-59 years of age. Most of the patients were male comprising of 56.08% of the total population. For the treatment of hypertension, both monotherapy and combination therapy were followed. In Monotherapy, amlodipine was most prescribed with the percentage of 66%, followed by Losartan (17%). For combination therapy, a two drug combination of Amlodipine and Losartan was projected to the most commonly prescribed combination with a percentage of 59.18% followed by Losartan and Hydrochlorthiazide (26.5%)
Conclusion: The majority of the treated patients were prescribed on monotherapy (66.21%). Antihypertensives given were consistent with JNC VIII do not use abbreviation guidelines. However, there remains potential room for improvement in drug utilization and a critical need for better blood pressure control.